发给老马备查:/ D3 E' { B% c- z1 r3 k0 G
滴水察海(69304838) 15:23:23
; S4 d3 H; u0 r$ G, u5 a老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
$ ]% _% {. l, q. q2 D- \2 N2 M吉非替尼和S-1连用的依据
9 V1 B3 A) w, N* f. J7 t: ]* QGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' O. J. o2 T4 p# _2 O9 M0 P' H是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达 D2 i" e" X0 }! O! j$ I& W
这样是不是推理出,耐药后,可以用S-1和培美了?% U# n# q L+ Y
结论:2 f, W$ }; D" X* G/ F E# L+ \
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |